NASA (National Aeronautics and Space Administration) is the world's biggest space agency and the national independent space research organization of the USA. 

ISRO (Indian Space Research Organization) is the government headed space research agency and one of the leading space organizations in the current world. 

These both agencies are often linked, compared, talked about in the league of space research organizations as well as the entire aeronautics world. 

From the very definition, motto, slogan, work culture, daily to daily operations, achievements......the list goes on. 

Secrets to conspiracy theories against both are quite often in the aeronautics interested community. When compared on the very line of comparison what people do lack in their backend understanding is the understanding of core differences amongst the two. 

Let's try to understand the core differences and outline a sensible yet informative conclusion as to how both ISRO and NASA are different. 

Motto 

According to ISRO's website "Our vision is to harness space technology for national development while pursuing space science research and planetary exploration." 

According to NASA's Wikipedia page, it's primary motto is   

"For the Benefit of All"

History

NASA: Year of inception: 1958

ISRO: Year of inception: 1969

Annual Budget 

NASA: US $ 19.5 billion

ISRO: US $ 1.4 billion

Objective

As indicated by NASA, it leads its work in four head directives, called mission directorates:  

Aeronautics: oversees investigate concentrated on fulfilling the worldwide need for air versatility in manners that are all the more ecologically neighborly and economical, while additionally grasping progressive innovation from outside avionics.  

Human Exploration and Operations: centers around International Space Station tasks, the advancement of business spaceflight abilities and human investigation past the low-Earth circle.  

Science: investigates the Earth, close planetary system and universe past; outlines the best course of revelation; and receives the rewards of Earth and space investigation for society.  

Space Technology: quickly creates, enhances, illustrates, and imbues progressive, high-result innovations that empower NASA's future missions while giving monetary advantage to the country. 

According to ISRO, it's the main objective is as underlined:-  

“The main objective is to develop space technology and its application to various national tasks. The Space Commission formulates the policies and oversees the implementation of the Indian space programme to promote the development and application of space science and technology for the socio-economic benefit of the country.”

Major Achievements  

NASA is the main space administration, which sent satellites to each of the 8 planets, including the dwarf planet, Pluto.  

ISRO is the major space organization, which sent the most elevated satellites into the space that is 104.  

NASA accomplished a notable amazing occasion that is an interstellar mission,voyager1&2  

ISRO achieved a notable occasion in the world, that it is the one in particular which prevailing to send a spacecraft to Mars in the very first attempt. 

So NASA can be understood as the"Big Boss"in the space world especially when the comparison is drawn with ISRO which is the "new rising star" set to achieve an unparallel set of goals.